辣根过氧化物酶
化学
催化作用
星团(航天器)
激进的
组合化学
活动站点
反应性(心理学)
纳米技术
光化学
酶
材料科学
有机化学
计算机科学
病理
程序设计语言
替代医学
医学
作者
Jieru Zhang,Tai-Sing Wu,Ho Viet Thang,Kai-Yu Tseng,Xiaodong Hao,Bingshe Xu,Hsin-Yi Tiffany Chen,Yung-Kang Peng
出处
期刊:Small
[Wiley]
日期:2021-11-25
卷期号:18 (5): 2104844-2104844
被引量:18
标识
DOI:10.1002/smll.202104844
摘要
Single-atom catalysts have attracted attention in the past decade since they maximize the utilization of active sites and facilitate the understanding of product distribution in some catalytic reactions. Recently, this idea has been extended to single-atom nanozymes (SAzymes) for the mimicking of natural enzymes such as horseradish peroxidase (HRP) often used in bioanalytical applications. Herein, it is demonstrated that those SAzymes without constructing the reaction pocket of HRP still undergo the OH radical-mediated pathway like most of the reported nanozymes. Their positively charged single-atom centers resulting from support electronegative oxygen/nitrogen hinder the reductive conversion of H2 O2 to OH radicals and hence display low activity per site. In contrast, it is found that this step can be facilitated over their metallic counterparts on cluster nanozymes with much higher site activity and atom efficiency (cf. SAzymes with 100% atom utilization). Besides the mimicking of HRP in glucose detection, cluster nanozymes are also demonstrated as a better oxidase mimetic for glutathione detection.
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