化学
烷基化
卤化物
吡啶
邻苯二甲酰亚胺
镍
光催化
激进的
氧化还原
组合化学
催化作用
嘧啶
小学(天文学)
有机化学
立体化学
邻苯二甲酰亚胺
光催化
物理
天文
作者
Nicole Erin Behnke,Zachary S. Sales,Minyan Li,Aaron T. Herrmann
标识
DOI:10.1021/acs.joc.1c01625
摘要
Herein a method for the radical alkylation of heteroaryl halides that relies upon the combination of photoredox and nickel catalysis is described. The use of aliphatic N-(acyloxy)phthalimides as redox-active esters affords primary and secondary radicals for the decarboxylative dual cross-coupling with pyrimidine and pyridine heteroaryl chlorides, bromides, and iodides. The method provides an additional synthetic tool for the incorporation of medicinally relevant heterocyclic motifs.
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