A Tetraarylpyrrole‐Based Phosphine Ligand for the Palladium‐Catalyzed Amination of Aryl Chlorides

Abstract A tetraarylpyrrole‐based phosphine ligand L1 in combination with Pd(dba) 2 provided a catalyst for the Buchwald‐Hartwig amination reaction. A variety of amines were rapidly coupled with aryl chlorides at a Pd loading of 0.5 mol%. The selective monoarylation of aliphatic primary amines was achieved in the presence of 0.8 equiv. water. Comparison experiments were also conducted, which revealed that the catalytic activity of L1 is superior to representative phosphine ligands in the Pd‐catalyzed C−N coupling of various amines. magnified image