One-step synthesis of ketones from car☐ylic acids and grignard reagents in the presence of a nickel(II)-phosphine catalyst.

Abstract A one-step synthesis of diaryl and alkyl-aryl ketones by the reaction of car☐ylic acid with Grignard reagents in the presence of NiCl 2 (Ph 2 PCH 2 CH 2 PPh 2 ) as catalyst is described. In the nickel-catalyzed Grignard reaction the formation of alcohols is nearly completely suppressed.