Efficient Oxidative Chlorination of Aromatics on Saturated Sodium Chloride Solution

Abstract An efficient metal‐free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy‐to‐handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical.