Indium‐Catalyzed Cycloisomerization of ω‐Alkynyl‐β‐ketoesters into Six‐ to Fifteen‐Membered Rings

Many different sizes of rings available: Heating ω-alkynyl-β-ketoesters in the presence of In(NTf2)3 (Tf=trifluoromethanesulfonyl) produces six- to fifteen-membered ring products in good yields. The reaction features low catalyst loading and moderately dilute conditions, and the formation of medium-sized rings is sometimes faster than that for the corresponding six-membered rings. A synthesis of (±)-muscone is also reported. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702928_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.