microRNA Regulation of Inflammatory Responses

炎症 生物 小RNA 自身免疫 免疫学 炎症反应 癌症 生物信息学 神经科学 计算生物学 免疫系统 基因 遗传学
作者
Ryan M. O’Connell,Dinesh S. Rao,David Baltimore
出处
期刊:Annual Review of Immunology [Annual Reviews]
卷期号:30 (1): 295-312 被引量:857
标识
DOI:10.1146/annurev-immunol-020711-075013
摘要

The mammalian inflammatory response is a rapid and complex physiological reaction to noxious stimuli including microbial pathogens. Although inflammation plays a valuable role in combating infection, its dysregulation often occurs in people and can cause a variety of pathologies, ranging from chronic inflammation, to autoimmunity, to cancer. In recent years, our understanding of both the cellular and molecular networks that regulate inflammation has improved dramatically. Although much of the focus has been on the study of protein regulators of inflammation, recent evidence also points to a critical role for a specific class of noncoding RNAs, called microRNAs (miRNAs), in managing certain features of the inflammatory process. In this review, we discuss recent advances in our understanding of miRNAs and their connection to inflammatory responses. Additionally, we consider the link between perturbations in miRNA levels and the onset of human inflammatory diseases.
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