癌肉瘤
病理
生物
卵黄囊
畸胎瘤
卵巢
卵巢畸胎瘤
生殖细胞肿瘤
未成熟畸胎瘤
癌
胚胎
医学
内分泌学
细胞生物学
化疗
遗传学
作者
Olga F. García-Galvis,Claudia Cabrera-Ozoria,José M. García Fernández,Simona Stolnicu,Francisco F. Nogales
出处
期刊:International Journal of Gynecological Pathology
[Ovid Technologies (Wolters Kluwer)]
日期:2008-10-01
卷期号:27 (4): 515-520
被引量:34
标识
DOI:10.1097/pgp.0b013e31817b06c7
摘要
This paper reports a unique stage IV complex ovarian carcinosarcoma in a 69-year patient that had malignant mixed müllerian epithelial and mesenchymal components and also other malignant differentiation such as neuroectodermal (small cell, neuroendocrine, neuroglial, neuronal, and melanocytic) and endodermal (yolk sac tumor) tissues and trophoblastic cells. As its phenotype comprised elements derived embryologically from the 3 germ layers, it posed the problem of differentiating it from a teratoma originated from germ cells, with which it shared a trilaminar type differentiation. It was different from a teratoma as it coexisted with, and possibly originated from, a somatic tumor, namely a characteristic endometrioid adenocarcinoma. All neoplastic tissue patterns present in the neoplasm were malignant per se without an apparent gradient of maturation or presence of organoid structures.
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