外周血单个核细胞
蜕膜
刺激
免疫学
抗原
内分泌学
前列腺素E
内科学
脂多糖
PMOS逻辑
壁酰二肽
生物
男科
化学
怀孕
免疫系统
医学
胎盘
胎儿
生物化学
体外
遗传学
物理
晶体管
量子力学
电压
作者
Masahiko Mizuno,Koji Aoki,T. Kimbara
标识
DOI:10.1111/j.1600-0897.1994.tb00865.x
摘要
PROBLEM: Roles of decidual macrophages (DMs) in the maintenance of early pregnancy was determined by comparing three of their functions, antigen presentation, immunoregulation, and lymphokine production, with those of peripheral monocytes (PMos) isolated from the same subjects. METHOD: The antigen‐presenting capacity of DMs was examined by the one‐way mixed lymphocyte reaction (MLR) in which accessory cell‐depleted mononuclear cells isolated from pregnant women were used as responders. The effect of DMs on cellular immunity was investigated by inhibition tests of either one‐way MLR or phytohemagglutinin stimulation. The production of interleukin‐1 (IL‐1) and prostaglandin E 2 (PGE 2 ) by DMs following lipopolysaccharide stimulation was examined. RESULTS: Addition of increasing concentrations of DMs to the culture resulted in a concentration‐dependent proliferative response, as well as with PMos. In both assays, a stronger suppression was observed in the presence of DMs from normal pregnant women compared with PMos from the same subjects. DMs were found to secrete significantly lower levels of IL‐1 α and IL‐1β than PMos. No difference in PGE 2 production was observed between DMs and PMos. CONCLUSIONS: These findings suggest that DMs present in human early decidual tissue have a capacity for allo‐antigen presentation, a higher suppressive activity, and a lower capacity to produce IL‐1 than their peripheral counterparts.
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