神经科学
神经再支配
生物
轴突切开术
黑素psin
视交叉上核
视网膜
PTEN公司
中枢神经系统
细胞生物学
PI3K/AKT/mTOR通路
信号转导
感光色素
作者
Songshan Li,Qinghai He,Hao Wang,Xiaoxue Tang,Kam Wing Ho,Xin Gao,Qian Zhang,Yang Shen,Annie S T Cheung,Francis T. W. Wong,Yung Hou Wong,Nancy Y. Ip,Liwen Jiang,Wing-Ho Yung,Kai Liu
标识
DOI:10.1016/j.nbd.2014.09.019
摘要
Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring.
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