内科学
内分泌学
甘油三酯
脂肪肝
绞股蓝
丙二醛
脂肪变性
化学
胆固醇
非酒精性脂肪肝
丙氨酸转氨酶
氧化应激
医学
脂质代谢
脂肪酸合酶
色谱法
萃取(化学)
疾病
作者
Renan Qin,Jianyu Zhang,Chuyuan Li,Xiaoqi Zhang,Aizhen Xiong,Feng Huang,Zhen Yin,Kongyan Li,Wenyu Qin,Mingzhen Chen,Shubing Zhang,Lingyi Liang,Huiye Zhang,Hong Nie,Wen‐Cai Ye
标识
DOI:10.1007/s12272-012-0715-5
摘要
In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol. Male SD rats were divided into seven groups: control, model, lovastatin, silymarin, gypenosides high-, medium- and low-treatment groups. The latter 6 groups were fed high-fat and cholesterol diet and administered alcohol intragastricly once a day. Body weight was measured every week for 10 weeks, and the hepatic index was measured after 10 weeks. Compared with model group, levels of serum triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and low density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) activity in both serum and hepatic tissue and mRNA and protein level of peroxisome proliferator-activated receptor α (PPAR-α) were significantly increased. Moreover, hepatic steatosis and mitochondrial damage were improved. These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress.
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