生物
细胞生物学
祖细胞
脂肪组织
CD81号
整合素
脂肪细胞
细胞
信号转导
干细胞
免疫学
内分泌学
遗传学
病毒
丙型肝炎病毒
作者
Yasuo Oguri,Kosaku Shinoda,Hyeonwoo Kim,Diana Alba,W. Reid Bolus,Qiang Wang,Zachary D. Brown,Rachana Pradhan,Kazuki Tajima,Takeshi Yoneshiro,Kenji Ikeda,Yong Chen,Rachel T. Cheang,Kazuyuki Tsujino,Caroline R. Kim,Vanille Greiner,Ritwik Datta,Chen-Yen Yang,Kamran Atabai,Michael T. McManus,Suneil K. Koliwad,Bruce M. Spiegelman,Shingo Kajimura
出处
期刊:Cell
[Elsevier]
日期:2020-08-01
卷期号:182 (3): 563-577.e20
被引量:161
标识
DOI:10.1016/j.cell.2020.06.021
摘要
Summary
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with αV/β1 and αV/β5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis.
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