SOX2
基底细胞癌
信使核糖核酸
医学
癌症研究
基底细胞
基础(医学)
转移
逆转录酶
核糖核酸
病理
癌症
生物
内科学
转录因子
基因
遗传学
胰岛素
作者
Reza Ahmadi‐Beni,Fatemeh Vand‐Rajabpour,Mohamadreza Ahmadifard,Maryam Daneshpazhooh,Pedram Noormohammadpour,Javad Rahmati,Kambiz Kamyab Hesari,Mehdi Yaseri,Mina Tabrizi
标识
DOI:10.4103/ijd.ijd_387_18
摘要
Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated. We hypothesized BCC, contrary to SCC, and melanoma, could be a suitable model to study mechanisms which attenuate tumor metastasis. The aim of this study was to examine the messenger RNA (mRNA) expression levels of sox2, zeb1, and p21 in BCC.Twenty-seven nonmetastatic BCC and twelve normal skin samples were evaluated using real-time reverse transcriptase polymerase chain reaction.The stemness marker sox2 demonstrated marked down-regulation, but zeb1 and p21 showed no significant change.Here, we report a negative association between sox2 mRNA expression level and nonmetastatic BCC, thus, providing a likely explanation for the fact that normal skin is more reliant on sox2 than BCC. BCC may be using decreased sox2 mRNA to remain incognito from metastatic potential.
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