免疫组织化学
生物标志物
食管癌
医学
食管鳞状细胞癌
肿瘤科
临床意义
发育不良
内科学
阶段(地层学)
病理
癌
淋巴结
癌症研究
癌症
生物
古生物学
生物化学
作者
K R Haye,Sruthi Babu,Lyanne Oblein,Rajarsi Gupta,Ali Akalin,Luisa F. Escobar‐Hoyos,Kenneth R. Shroyer
出处
期刊:Applied Immunohistochemistry & Molecular Morphology
日期:2020-06-16
卷期号:29 (2): 144-151
被引量:6
标识
DOI:10.1097/pai.0000000000000862
摘要
The major roles of keratin 17 (K17) as a prognostic biomarker have been highlighted in a range of human malignancies. However, its relevance to esophageal squamous cell carcinoma (ESCC) remains unexplored. In this study, the relationship between K17 expression and clinicopathologic parameters and survival were determined by RNA sequencing (RNA-Seq) in 90 ESCCs and by immunohistochemistry (IHC) in 68 ESCCs. K17 expression was significantly higher in ESCC than in paired normal tissues at both the messenger RNA and protein levels. K17 messenger RNA and staining by IHC were significantly correlated with aggressive characteristics, including advanced clinical stage, invasion depth, and lymph node metastases; and were predictive of poor prognosis in advanced disease patients. Furthermore, K17 expression was detected by IHC in high-grade premalignant lesions of the esophageal mucosa, suggesting that K17 could also be a biomarker of dysplasia of the esophageal mucosa. Overall, this study established that K17 is a negative prognostic biomarker for the most common subtype of esophageal cancer.
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