Ectopic lipid accumulation and chronic kidney disease

Altered lipid metabolism,especially ectopic lipid accumulation,is an important contributors to the progression of chronic kidney disease (CKD).Recent studies suggest that increasing uremic toxin may lead to ectopic lipid accumulation,and the disturbance of inherent adipose tissue is the central part of lipid redistribution in CKD.Ectopic lipid accumulation severely affects the prognosis of patients with CKD by accelerating kidney injury,inducing insulin resistance and increasing cardiovascular events.Related studies are helpful to improve our understanding of abnormal lipid metabolism of CKD as well as to find out the therapeutic target of ectopic lipid accumulation. Key words: Ectopic lipid accumulation ;  Chronic kidney disease ;  Lipid metabolism ;  Lipotoxicity