纳米凝胶
肉桂
壳聚糖
肉桂酸
化学
核化学
傅里叶变换红外光谱
材料科学
有机化学
化学工程
药物输送
卡西亚
中医药
替代医学
病理
工程类
医学
作者
Stephanne Yonara Barbosa de Carvalho,Regiamara Ribeiro Almeida,Natália Aparecida Rocha Pinto,Caroline de Mayrinck,Sara S. Vieira,Juliana F.S. Haddad,Alexandre A. Leitão,Luiz Gustavo de Lima Guimarães
标识
DOI:10.1016/j.ijbiomac.2020.10.247
摘要
Chemical modifications in the chitosan structure may result in obtaining a new material with improved chemical properties, such as an ability to encapsulate lipophilic compounds. This study aimed to synthesize cinnamic acid grafted chitosan nanogel to encapsulate the essential oils of Syzygium aromaticum and Cinnamomum ssp., in order to develop a material to be applied in the control of dermatophytosis caused by the fungus Microsporum canis. The cinnamic acid graft in chitosan was verified by the Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), Solid State Nuclear Magnetic Resonance of the 13C Nucleus (13C SSNMR) and Thermal analysis coupled to mass spectrometry (TG-MS) techniques. The nanogel obtained showed affinity for the essential oils of S. aromaticum and Cinnamomum, with encapsulation efficiencies equal to 74% and 89%, respectively. When in an aqueous medium the nanogel with the encapsulated essential oils was able to form stable nanoparticles with average sizes of 176.0 ± 54.3 nm and 263.0 ± 81.4 nm. The cinnamic acid grafted chitosan nanogel showed antifungal activity in vitro against M. canis, inhibiting up to 53.96% of its mycelial growth. Complete inhibition of mycelial growth was achieved by the nanogel with encapsulated essential oils. The results found in this work demonstrated the development of a material with potential application in the control of dermatophytosis caused by the fungus M. canis.
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