Nitroxide radical contrast agents for safe magnetic resonance imaging: progress, challenges, and perspectives

H relaxation mechanisms, they have great potential to realize clinical translation among many metal-free MRI contrast agents. At present, NRCAs have been proposed as an effective substitute for metal-based MRI contrast agents. Herein, this review first briefly introduces NRCAs, including their composition, classification, mechanism of action, application performances and advantages. Then, this review highlights the progress of NRCAs, including small molecule-based NRCAs and polymer-based NRCAs. Finally, this review also discusses the challenges and future perspectives of NRCAs.