持续气道正压
医学
阻塞性睡眠呼吸暂停
心脏病学
代谢综合征
间歇性缺氧
糖尿病
睡眠呼吸暂停
内科学
血压
风险因素
缺氧(环境)
气道正压
重症监护医学
内分泌学
化学
有机化学
氧气
作者
Gerard Torres,M. Sanchez De La Torre,Lucía Pinilla,Ferrán Barbé
标识
DOI:10.1016/j.arteri.2024.01.004
摘要
Patients with obstructive sleep apnea (OSA) experience repetitive episodes of upper airway obstruction due to recurrent collapse during sleep. This leads to intermittent hypoxia episodes, which, through complex pathophysiological mechanisms, trigger sympathetic overactivation, endothelial dysfunction, hypercoagulation, and metabolic dysregulation. Consequently, other cardiovascular risk factors such as hypertension, metabolic syndrome, and diabetes are induced. Furthermore, this enhances target organ damage, affecting the heart, arteries, and kidneys, leading to an increased risk of cardiovascular morbidity and mortality. Among the various treatments for OSA, Continuous Positive Airway Pressure (CPAP) has been extensively studied. To date, this treatment has shown mild benefits in reducing blood pressure, particularly noticeable in patients with resistant hypertension. Furthermore, CPAP treatment appears to reduce cardiovascular events, both in primary and secondary prevention, though this benefit is limited to individuals with good compliance (CPAP use ≥4h/night). Future research perspectives in OSA seem to focus on identifying patients in whom the condition significantly influences cardiovascular risk, thus determining those who would benefit the most from treatment in the reduction of cardiovascular risk.
科研通智能强力驱动
Strongly Powered by AbleSci AI