多重耐药
三萜类
立体化学
化学
二维核磁共振波谱
生物化学
抗生素
作者
Sibei Wang,Zhaoyu Shi,Han Zhang,Jiantong Hou,Dong‐Ho Lee,Jing Xu,Yuanqiang Guo
标识
DOI:10.1016/j.phytochem.2023.113867
摘要
Four undescribed cycloartane-type triterpenoids (1-4) and seven undescribed steroids (6-12), along with five known analogues (5 and 13-16), were isolated from the leaves of Trichilia connaroides. Their structures were identified based on the NMR data and HRESIMS, and the absolute configurations were determined through single-crystal X-ray diffraction analysis, Mosher's method, and ECD calculations. The multidrug resistance (MDR) reversal activities of all the isolates were assessed, and compounds 10 and 11 showed significant activities to reverse the MDR of MCF-7/DOX cells with IC50 values of 2.90 and 3.76 μM, respectively. These bioactive compounds may bring fresh insights into the research and development of MDR reversal agents.
科研通智能强力驱动
Strongly Powered by AbleSci AI