Construction of Thioglycoside Bond via asymmetric organocatalyzed sulfa-Michael/Aldol reaction: Access to 4’-thionucleosides

Thioglycoside bond formation via asymmetric sulfa-Michael/aldol reaction of (E)-β-nucleobase acrylketones and 1,4-dithiane-2,5-diol has been developed with a cinchona alkaloid-derived bifunctional squaramide chiral catalyst. Diverse purine, benzimidazole, and midazole are well...