Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair

. Mechanistically, RNA-sequencing elucidated that the POC-ACP scaffold promoted osteogenic differentiation by activating the AMPK and TGF-β signaling pathways. Our study provides a novel biomimetic mineralized scaffold with ACP stabilization, offering a promising alternative for clinical bone defect repair.