安普克
脂肪生成
NAD+激酶
AMP活化蛋白激酶
二甲双胍
脂质代谢
西妥因1
生物
磷酸化
化学
内分泌学
生物化学
蛋白激酶A
下调和上调
酶
糖尿病
基因
作者
Lili Cheng,R. N. V. Krishna Deepak,Guoqiang Wang,Ziyi Meng,Lei Tao,Mengqing Xie,Wenna Chi,Yuming Zhang,Mingming Yang,Yilie Liao,Ruiqun Chen,Yu Liang,Junyu Zhang,Yuedong Huang,Weihua Wang,Zhiying Guo,Yunfang Wang,Jiandie D. Lin,Hao Fan,Ligong Chen
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2023-02-20
卷期号:78 (6): 1828-1842
被引量:64
标识
DOI:10.1097/hep.0000000000000314
摘要
Our findings reveal that SLC25A47, a hepatocyte-specific mitochondrial NAD + transporter, is one of the pharmacological targets of metformin and regulates lipid homeostasis through AMPKα, and may serve as a potential drug target for treating NAFLD and HCC.
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