材料科学
自愈水凝胶
佩多:嘘
生物相容性
右旋糖酐
导电聚合物
组织工程
纳米技术
生物医学工程
复合材料
聚合物
化学
高分子化学
医学
生物化学
冶金
作者
Chaojie Yu,Zhiwei Yue,Hong Zhang,Mingyue Shi,Mengmeng Yao,Qingyu Yu,Min Liu,Bingyan Guo,Haitao Zhang,Leqi Tian,Hong Sun,Fanglian Yao,Junjie Li
标识
DOI:10.1002/adfm.202211023
摘要
Abstract Currently, although conducting polymers have exhibited potential electrophysiological modulation, designing bioinspired ultra‐histocompatible conducting polymers remains a long‐standing challenge. Moreover, the water dispersibility, conductivity, and biocompatibility of conducting polymers are incompatible, which restricts their application in tissue engineering. Herein, a multilevel template dispersion strategy is presented to produce poly(3,4‐ethylenedioxythiophene):(dextran sulfate/carboxymethyl chitosan) (PEDOT:(DSS/CMCS)) with biocompatibility superior to that of commercial poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) without sacrificing processability and conductivity. The PEDOT:(DSS/CMCS) and oxidized dextran solutions form an injectable PEDOT‐based hydrogel (PDCOH) mediated by dynamic covalent imine bonds under mild conditions. The PDCOH has a tissue‐matched modulus and conductivity to adapt to the mechanical environment of dynamic tissue and modulate fibrosis‐induced electrical decoupling. The PDCOH combined with adipose‐derived stem cells demonstrates superior cardiac repair effects over cell suspensions and nonconductive hydrogels, inhibiting ventricular remodeling, reducing fibrous scarring, promoting vascular regeneration, and restoring electrophysiological and pulsatile functions.
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