EZH2型
视网膜母细胞瘤
PRC2
免疫组织化学
视网膜母细胞瘤蛋白
癌症研究
生物
细胞周期
细胞生长
细胞
组蛋白
免疫学
遗传学
基因
作者
Zhuangling Lin,Lijuan Tang,Shuxia Chen,Wenxin Zhang,Jintian Lin,Huanhuan Gao,Ping Zhang
出处
期刊:Ophthalmic Research
[S. Karger AG]
日期:2023-01-01
卷期号:: 1014-1019
摘要
The enhancer of zeste homolog 2 (EZH2) is a member of the polycomb repressive complex 2 (PRC2) and is important in cell-cycle regulation. Increased expression of EZH2 has been reported in retinoblastoma (RB). The aim of the study was to determine EZH2 expression, compare this with clinicopathological parameters in RB, and assess its relationship with tumor cell proliferation.Ninety-nine retrospective cases of enucleated RB were included in the present study. Expression of EZH2 and the marker of cell proliferation, Ki67, were investigated by immunohistochemistry.Among the 99 cases of RB in this study, EZH2 was found highly expressed (positive expression rate ≥70%) in 92 cases. EZH2 was expressed in tumor cells but absent in normal retinal tissues. The expression of EZH2 was positively linked to Ki67 expression (r = 0.65, p < 0.001).Elevated EZH2 expression was found in most RB cases, indicating that EZH2 could be a potential therapeutic target for RB.
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