材料科学
表面改性
聚乙二醇
盐酸阿霉素
荧光
聚合
胶束
介孔材料
介孔二氧化硅
组合化学
纳米技术
药物输送
共轭体系
聚合物
化学工程
有机化学
化学
水溶液
阿霉素
物理
催化作用
复合材料
化疗
医学
量子力学
外科
工程类
作者
Hyungsik Jung,Kyungjin Cho,Sihwa Joo,Mina Lee,Myeong Yun Kim,Ik-Hwan Kwon,Nam Woong Song,Jae-Hyeok Shim,Keir C. Neuman
标识
DOI:10.1021/acsami.3c05443
摘要
Fluorescent nanodiamonds (FNDs) are versatile nanomaterials with promising properties. However, efficient functionalization of FNDs for biomedical applications remains challenging. In this study, we demonstrate mesoporous polydopamine (mPDA) encapsulation of FNDs. The mPDA shell is generated by sequential formation of micelles via self-assembly of Pluronic F127 (F127) with 1,3,5-trimethyl benzene (TMB) and composite micelles via oxidation and self-polymerization of dopamine hydrochloride (DA). The surface of the mPDA shell can be readily functionalized with thiol-terminated methoxy polyethylene glycol (mPEG-SH), hyperbranched polyglycerol (HPG), and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The PEGylated FND@mPDA particles are efficiently taken up by, and employed as a fluorescent imaging probe for, HeLa cells. HPG-functionalized FND@mPDA is conjugated with an amino-terminated oligonucleotide to detect microRNA via hybridization. Finally, the increased surface area of the mPDA shell permits efficient loading of doxorubicin hydrochloride. Further modification with TPGS increases drug delivery efficiency, resulting in high toxicity to cancer cells.
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