NMDA受体
脑血流
硝普钠
内分泌学
内科学
化学
白屈菜红碱
医学
麻醉
蛋白激酶C
受体
一氧化氮
生物化学
酶
作者
Chun‐Kai Hsu,Shang‐Jen Chang,Li-Yi Lim,Hsi‐Hsien Chang,Stephen Shei‐Dei Yang
出处
期刊:Journal of Vascular Research
[S. Karger AG]
日期:2023-01-01
卷期号:60 (3): 137-147
摘要
N-methyl-D-aspartate (NMDA) receptors were found to be dysfunctional in hypertensive rats. Methyl palmitate (MP) has been shown to diminish the nicotine-induced increase in blood flow in the brainstem. The aim of this study was to determine how MP modulated NMDA-induced increased regional cerebral blood flow (rCBF) in normotensive (WKY), spontaneously hypertensive (SHR), and renovascular hypertensive (RHR) rats. The increase in rCBF after the topical application of experimental drugs was measured using laser Doppler flowmetry. Topical NMDA application induced an MK-801-sensitive increase in rCBF in anesthetized WKY rats, which was inhibited by MP pretreatments. This inhibition was prevented by pretreatment with chelerythrine (a PKC inhibitor). The NMDA-induced increase in rCBF was also inhibited by the PKC activator in a concentration-dependent manner. Neither MP nor MK-801 affected the increase in rCBF induced by the topical application of acetylcholine or sodium nitroprusside. Topical application of MP to the parietal cortex of SHRs, on the other hand, increased basal rCBF slightly but significantly. MP enhanced the NMDA-induced increase in rCBF in SHRs and RHRs. These results suggested that MP had a dual effect on the modulation of rCBF. MP appears to play a significant physiological role in CBF regulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI