生物
自噬
复制(统计)
病毒学
病毒复制
乙型肝炎病毒
细胞生物学
病毒
HBx公司
遗传学
细胞凋亡
作者
Yu-Chen Chuang,Jing-Hsiung Ou
出处
期刊:Autophagy
[Informa]
日期:2022-09-05
卷期号:19 (4): 1357-1358
被引量:2
标识
DOI:10.1080/15548627.2022.2117974
摘要
ABSTRACTAutophagy (i.e. macroautophagy) plays a significant role in the replication of hepatitis B virus (HBV). In our recent study, we examined the underlying mechanism and discovered that autophagic membranes participated in different steps of the HBV life cycle. We found that phagophores are involved in the assembly of HBV nucleocapsids, autophagosomes participate in the trafficking of HBV nucleocapsids, amphisomes likely participate in the maturation and egress of mature HBV particles, and autolysosomes negatively regulate HBV replication. Our work provides important insights for understanding the relationship between autophagic membranes and HBV replication and raises the possibility of targeting the autophagic pathway for the development of novel drugs against HBV.Keywords: HBV assembly and egressphagophoresautophagosomesamphisomessecretory autophagy Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was supported by the National Institutes of Health [AI129540, AI145813, AI148304].
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