One‐Pot Synthesis of Styryl‐Linked Polycyclic‐Fused Pyridine Derivatives by a Multicomponent Strategy

Abstract In the present study, new styryl‐linked pyridine derivatives fused with pyrazole were synthesized by the one‐pot reaction of α, β‐ unsaturated aldehyde, cyclic‐1,3‐diketone, and 5‐aminopyrazole in DMSO at 100 °C in an open air. All the products were characterized by FTIR, 1 H NMR, 13 C NMR, and HRMS. Single crystal XRD of one product 4i was done to confirm the structure. 2C─C and 1C─N bonds are formed in one‐pot. Various bioactive moieties such as pyridine, pyrazole, and styryl are present in our synthesized hybrid heterocyclic scaffold. This methodology is also applicable in gram‐scale synthesis. Operational simplicity, greener reaction condition, good yields of the products, and easy purification process are the notable features of this methodology.