15th Anniversary ‐ Review‐type Compilation (14/2024)Oxidative N‐formylation of amines to formamides

Formamides are an important class of amine chemicals with a wide range of applications in industry, synthetic chemistry and materials, and their synthesis has gained increasing attention. Among the various methods developed, oxidative N‐formylation of amines with methanol, formaldehyde and non‐C1 feedstocks constitutes an attractive one, especially using green oxidant such as air, O2, and H2O2, due to satisfied production efficiency, mild reaction conditions and effective cost. Although great progress has been made in this direction, a review focusing on this aspect is almost vacant. This review summarizes the recent development on the oxidative N‐formylation of amines to formamides according to the kinds of formyl sources and oxidants.