皮肤白血病
慢性粒单核细胞白血病
医学
病理
背景(考古学)
慢性肉芽肿性疾病
骨髓
白血病
髓系白血病
髓样
免疫学
骨髓增生异常综合症
生物
古生物学
作者
Mar García‐García,Julia Jiménez Elbaile,Gemma Azaceta,Marta Lorda,Lucía Prieto‐Torres
摘要
Abstract Traditionally, skin involvement in chronic myelomonocytic leukemia (CMML) has been considered to be either specific (leukemia cutis) or non‐specific, with granulomatous dermatitis included in the latter group. More recently, the true nature of the myeloid cells present in the cutaneous infiltrates of this theoretically reactive dermatitis is being clarified with the use of new molecular techniques such as next‐generation sequencing. The same mutations in bone marrow (BM) myeloid neoplastic cells and in the cells of cutaneous infiltrates have been found. We present the case of a 77‐year‐old man who presented with spread and treatment‐resistant skin granulomatous lesions previous to the diagnosis of CMML. The same clonal mutations in SRSF2 , IDH1 , and RUNX1 were found in both skin and BM with resolution of the lesions after the initiation of azacytidine. In conclusion, we report an exceptional case in which specific granulomatous cutaneous lesions have preceded and allowed the earlier diagnosis of an underlying CMML and a review of all previous similar cases in the literature, including molecular alterations.
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