Addressing the Generalizability of AI in Radiology Using a Novel Data Augmentation Framework with Synthetic Patient Image Data: Proof-of-Concept and External Validation Classification Tasks in Multiple Sclerosis

Artificial intelligence (AI) models often face performance drops after deployment to external datasets. This study evaluated the potential of a novel data augmentation framework based on generative adversarial networks (GANs) that creates synthetic patient image data for model training to improve model generalizability. Model development and external testing were performed for a given classification task, namely the detection of new fluid-attenuated inversion recovery lesions at MRI during longitudinal follow-up of patients with multiple sclerosis (MS). An internal dataset of 669 patients with MS (