利培酮
精神分裂症(面向对象编程)
单核苷酸多态性
内科学
阳性与阴性症状量表
抗精神病药
医学
精神科
5-HT2A受体
多巴胺受体D2
精神病
肿瘤科
基因型
心理学
遗传学
生物
多巴胺
基因
受体
5-羟色胺受体
血清素
作者
Gurjit Kaur,Deepti Gupta,Bir Singh Chavan,Vikas Sinhmar,Rajendra Prasad,Adarsh Tripathi,Puneet Garg,Rajiv Gupta,Hitesh Khurana,Shiv Gautam,Mushtaq Ahmed Margoob,Jitender Aneja
标识
DOI:10.1016/j.ajp.2017.07.026
摘要
Risperidone is most commonly used as an antipsychotic in India for treatment of schizophrenia. However, the response to treatment with risperidone is affected by many factors, genetic factors being one of them. So, we attempted to evaluate the association between dopamine D2 (DRD2) receptor, serotonergic (5HT2A) receptor and CYP2D6 gene polymorphisms and response to treatment with risperidone in persons with schizophrenia from North India. It was a multicentric 12-weeks prospective study, undertaken in patients diagnosed with schizophrenia according to International Classification of Diseases 10th revision, Diagnostic Criteria for Research module (ICD-10 DCR). Patients were treated with incremental dosages of risperidone. Nine gene polymorphisms from three genes viz. DRD2, 5-HT2A and CYP2D6 along with socio-demographical and clinical variables were analyzed to ascertain the association in response to risperidone treatment. The change in the Positive and Negative Syndrome Scale (PANSS) was used to measure the outcome. Significant differences in the frequencies of single nucleotide proteins (SNPs) rs180498 (Taq1D) and rs 6305 (C516T) polymorphisms were found amongst the groups defined according to percent decline in PANSS. The CYP2D6*4 polymorphism differed significantly when drop outs were excluded from analysis. Presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone. Ser311Cys (rs1801028) mutation was absent in the North Indian patients suffering from schizophrenia.
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