膀胱镜检查
膀胱癌
系统回顾
科克伦图书馆
DNA甲基化
荟萃分析
泌尿系统
甲基化
生物标志物
肿瘤科
尿
梅德林
医学
生物
癌症
尿细胞学
内科学
生物信息学
接收机工作特性
生物化学
作者
Judith Bosschieter,Catrin Lutz,Loes I. Segerink,André N. Vis,Ellen C. Zwarthoff,R. Jeroen A. van Moorselaar,Bas W.G. van Rhijn,Martijn W. Heymans,Elizabeth P Jansma,Renske D.M. Steenbergen,Jakko A. Nieuwenhuijzen
出处
期刊:Epigenomics
[Future Medicine]
日期:2018-05-01
卷期号:10 (5): 673-687
被引量:20
标识
DOI:10.2217/epi-2017-0156
摘要
Aim: Several urinary hypermethylation-markers (hmDNA) have been described for bladder cancer (BC) detection, but none have been able to replace cystoscopy yet. We systematically reviewed and evaluated current literature on urinary hmDNA markers for BC diagnostics. Patients & methods: A systematic search of PubMed, EMBASE.com and The Cochrane Library up to February 2017 using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, was conducted. Results: A total of 30/42 studies included compared gene panels, with varying sensitivities (52–100%) and specificities (0–100%). Considerable heterogeneity across studies was observed and most was case–control studies. Conclusion: Reported diagnostic accuracy of urinary hmDNA for BC detection is highly variable and there is a lack of validation studies. Recent studies indicate that complementary markers are needed to allow for clinical implementation.
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