刺猬信号通路
刺猬
医学
肺癌
基底细胞癌
维莫德吉
癌症研究
平滑
临床试验
基础(医学)
髓母细胞瘤
肿瘤科
基底细胞
内科学
信号转导
生物
细胞生物学
胰岛素
作者
Anastasios Dimou,A Bamias,Helen Gogas,Konstantinos Syrigos
出处
期刊:Lung Cancer
[Elsevier]
日期:2019-07-01
卷期号:133: 56-61
被引量:13
标识
DOI:10.1016/j.lungcan.2019.05.004
摘要
Inhibitors of the hedgehog pathway are effective in patients with basal cell carcinoma and a subgroup of patients with medulloblastoma with active hedgehog signaling. Despite preclinical work suggesting otherwise, clinical trials in solid tumors of epithelial origin have not shown added benefit with these drugs. Here, we review the preclinical and clinical data of hedgehog pathway inhibition in the most common histologic types of lung cancer. We focus on highlighting areas of uncertainty, where further research might define a niche for hedgehog pathway inhibition in patients with lung cancer.
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