对映选择合成
钯
共晶体系
化学
催化作用
基质(水族馆)
胺气处理
生物转化
溶剂
深共晶溶剂
有机化学
组合化学
酶
海洋学
地质学
合金
作者
Juraj Paris,Aline Telzerow,Nicolás Ríos‐Lombardía,Kerstin Steiner,Helmut Schwab,Francisco Morís,Harald Gröger,Javier González‐Sabín
出处
期刊:ACS Sustainable Chemistry & Engineering
[American Chemical Society]
日期:2019-02-12
卷期号:7 (5): 5486-5493
被引量:44
标识
DOI:10.1021/acssuschemeng.8b06715
摘要
The first application of Deep Eutectic Solvents (DESs) in asymmetric bioamination of ketones has been accomplished. The amine transaminases (ATAs) turned out to be particularly stable in DES-buffer mixtures at a percentage of up to 75% (w/w) neoteric solvent. Moreover, this reaction medium was used to perform a chemoenzymatic cascade toward biaryl amines by coupling a Suzuki reaction sequentially with an enantioselective bioamination catalyzed by the recently discovered ATA from Exophiala xenobiotica (EX-ωTA). The solubilizing properties of DESs enabled the metal-catalyzed step at 200 mM loading of substrate and the subsequent biotransformation at 25 mM.
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