[Clinical parameters and the level of certain cytokines in blood and cerebrospinal fluid of patients with Parkinson's disease].

In the past decade, much attention has been given to immunological mechanisms of development of Parkinson's disease with special reference to the role of pro- and anti-inflammatory cytokines. The study was aimed at elucidating the cytokine status of PD patients taking account of the stage, duration, and clinical manifestations of the disease. It was shown that PD patients regardless of severity of the disease had elevated serum and liquor IL-1β and IL-6 levels compared with controls while the I-IRA level was decreased. Patients with predominantly left-side localization of PD had an elevated blood TNFα level. It was shown for the first time that the cytokine profile in PD patients varies with progression of disease. The high rate of progression was associated with the high liquor TNFα level and blood IL-1β level compared to the patients with moderate and slow progression. The blood IL-10 level was found to be related to the degree of anxiety and depression whereas the TNFα level correlated with the severity of cognitive deficit.