脑深部刺激
难治性抑郁症
神经调节
萧条(经济学)
心理学
心情
神经科学
情绪障碍
刺激
脑刺激
神经解剖学
重性抑郁障碍
医学
精神科
内科学
疾病
帕金森病
焦虑
经济
宏观经济学
作者
Robert Anderson,Mark A. Frye,Osama A. Abulseoud,Kendall H. Lee,Jane McGillivray,Michael Berk,Susannah J. Tye
标识
DOI:10.1016/j.neubiorev.2012.06.001
摘要
Deep brain stimulation (DBS), a neuromodulation therapy that has been used successfully in the treatment of symptoms associated with movement disorders, has recently undergone clinical trials for individuals suffering from treatment-resistant depression (TRD). Although the small patient numbers and open label study design limit our ability to identify optimum targets and make definitive conclusions about treatment efficacy, a review of the published research demonstrates significant reductions in depressive symptomatology and high rates of remission in a severely treatment-resistant patient group. Despite these encouraging results, an incomplete understanding of the mechanisms of action underlying the therapeutic effects of DBS for TRD is highlighted, paralleling the incomplete understanding of the neuroanatomy of mood regulation and treatment resistance. Proposed mechanisms of action include short and long-term local effects of stimulation at the neuronal level, to modulation of neural network activity.
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