姜黄素
抗菌剂
黏膜黏附
泊洛沙姆407
白色念珠菌
化学
固体脂质纳米粒
最小抑制浓度
嗜酸乳杆菌
变形链球菌
最低杀菌浓度
粒径
微生物学
色谱法
泊洛沙姆
细菌
药物输送
毒品携带者
生物化学
生物
有机化学
遗传学
益生菌
物理化学
共聚物
聚合物
作者
Heba A. Hazzah,Ragwa M. Farid,Maha M A Nasra,Walaa Hazzah,Magda A. El-Massik,Ossama Y. Abdallah
摘要
The purpose of the study was to prepare and characterize curcumin (Cur) solid lipid nanoparticles (CurSLN) with a high-loading capacity and chemical stability for the treatment of oral mucosal infection. CurSLN were formulated using different lipids, namely, Gelucire 39/01, Gelucire 50/13, Precirol, Compritol, and poloxamer 407 as a surfactant. Formulae were evaluated for their entrapment efficiency, particle size, and ex vivo mucoadhesion test. Microbiological evaluation was carried out on six microorganisms, five of which are the most commonly affecting oral cavity in terms of determination of minimum inhibitory concentration (MIC), and minimum bactericidal concentration. Transmission electron microscopy was conducted for ultrathin section for Candida albicans-treated with formulated Cur. The results showed high entrapment efficiency and stability enhancement for Cur powder. Significant amount of Cur was retained onto the mucosal tissue indicating preferential mucosal uptake. CurSLN showed higher antimicrobial activity as compared with Cur raw material and chemically stabilized Cur where it showed MIC (0.185, 0.09375, 0.75, 3, 1.5, and 0.1875 mg/mL) against Staphylococcus aureus, Streptococcus mutans, Viridansstrept, Escherichia coli, Lactobacillus acidophilus, and Candida albicans, respectively. The prepared lipid nanoparticles maintained Cur chemical stability and microbiological activity. The lack of local antimicrobial therapeutics with minimum side effects augments the importance of studying natural products for this purpose.
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