Clinical analysis of 121 cases of drug-induced liver injury by antituberculosis drug

Objective To investigate the clinical features,prevention and therapeutic measures of drug-induced liver injury by antituberculosis drug.Methods In 1 152 cases of tuberculosis patients in our hospital,121 cases had antituberculosis drug-induced liver injury.Drug-induced liver injury and its relation to age,initial treatment,retreatment and HBe infection were analyzed.Results The incidence of drug-induced liver injury was higher in patients ≥ 60-years-old,HBeAg + and undergoing retreatment than that in patients 60-years-old,HBeAg-and undergoing initial treatment (P0.001).The treatments of protecting liver,falling enzyme had good efficacy for recovering hepatic function.Conclusion Elderly,retreatment and HBe + are high-risk factors for drug-induced liver injury by antituberculosis drugs in tuberculosis patients.The hepatic function should be closely monitored in order to detect and treat drug-induced liver drug early and help patients complete antituberculosis chemotherapy.