The tetrabromobisphenol A was synthesized with acetonitrile as organic solvent from bisphenol-A,bromine and hydrogen peroxide.The influence on the production of bisphenol A was discussed by the way of feeding,stirring speed,the ratio of n(Br2)/n(BPA),temperature,the rate of oxidant.The production rate of bisphenol A can be up to 95.2% under given laboratory conditions.