微气泡
生物医学中的光声成像
材料科学
超声波
吲哚青绿
纳米棒
对比度(视觉)
生物医学工程
生物相容性材料
超声造影
纳米技术
放射科
光学
医学
外科
物理
作者
Andrew Hannah,Geoffrey P. Luke,Katheryne E. Wilson,Kimberly A. Homan,Stanislav Emelianov
出处
期刊:ACS Nano
[American Chemical Society]
日期:2013-12-18
卷期号:8 (1): 250-259
被引量:208
摘要
Recently, perfluorocarbon (PFC) nanodroplets were introduced as contrast agents for imaging and image-guided therapy. For example, in sonography, high-intensity ultrasound pulses were used to phase-transition liquid perfluorocarbon to produce gas microbubbles. More recently, perfluorocarbon nanodroplets with encapsulated gold nanorods were used as dual ultrasound/photoacoustic contrast agents. To expedite clinical translation, we synthesized and characterized ICG-loaded perfluorocarbon nanodroplets, i.e., constructs comprising biocompatible, nontoxic and biologically safe materials. We then demonstrated enhanced photoacoustic contrast through optically triggered phase transition of PFC nanodroplets and ultrasound contrast from the resulting PFC bubbles. We assessed the quality enhancement of photoacoustic and ultrasound images through analysis of contrast and contrast-to-noise ratio. We further investigated the changes in image contrast due to increased ambient temperature. Our studies suggest that ICG-loaded perfluorocarbon nanodroplets may become a valuable tool for various imaging modalities, and have promising therapeutic applications.
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