Synthesis progress of piperazine derivatives

Piperazine derivatives in the pharmaceutical and chemical industry have a wide range of applications.The synthesis method of species of alkyl piperazine derivatives,phenyl piperazine derivatives,diketopiperazines derivatives,isoflavones-piperazine derivatives,estrogen piperazine derivatives were described and the problems of the synthesis process of piperazine derivatives and research directions were pointed out.