下调和上调
生物
炎症
调节性B细胞
免疫系统
免疫学
白细胞介素10
B细胞
抗体
基因
生物化学
作者
Atsushi Mizoguchi,Emiko Mizoguchi,Hidetoshi Takedatsu,Richard S. Blumberg,Atul K. Bhan
出处
期刊:Immunity
[Elsevier]
日期:2002-02-01
卷期号:16 (2): 219-230
被引量:869
标识
DOI:10.1016/s1074-7613(02)00274-1
摘要
B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.
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