Power Generation versus Conventional Potentiostatic Operation of Prussian Blue Based (Bio)Sensors

Abstract We report on Prussian Blue based (bio)sensors displaying advantageous analytical performance characteristics when operated both in conventional three‐electrode regime powered by potentiostat and in power generation mode. ‘Self‐powered’ sensors are commonly aimed to produce sufficient energy for signalling and, thus, being energetically autonomous. In order to generate maximum energy output, the electrodes with high potential difference are preferable. In contrast, we propose the systems with the lowest potential difference between the working and the counter electrodes. Short‐circuiting the Prussian Blue modified working and the Ag|AgCl reference electrode, working electrode potential is adjusted to 0.00 V without potentiostat. The efficiency of the (bio)sensors in power generation mode is achieved due to high catalytic activity of Prussian Blue at 0.00 V versus Ag|AgCl reference. Here we discuss the benefits of the Prussian Blue based (bio)sensors operated through power generation in a short‐circuit regime without potentiostat, including an order of magnitude decreased noise and simplified readout. The multimodality of the sensors would provide their versatile functionality for the electroanalysis and elaboration of miniature highly sensitive wearable devices.