记忆T细胞
CD28
生物
人口
T细胞
干细胞
细胞生物学
免疫学
存储单元
免疫系统
医学
量子力学
环境卫生
物理
电压
晶体管
作者
Luca Gattinoni,Enrico Lugli,Yun Ji,Zoltán Pós,Chrystal M. Paulos,Máire F. Quigley,Jorge Reis Almeida,Emma Gostick,Zhiya Yu,Carmine Carpenito,Ena Wang,Daniel C. Douek,David A. Price,Carl H. June,Francesco M. Marincola,Mario Roederer,Nicholas P. Restifo
出处
期刊:Nature Medicine
[Springer Nature]
日期:2011-09-18
卷期号:17 (10): 1290-1297
被引量:1532
摘要
Whether there exists a human memory T cell population with stem cell–like properties of self-renewal and multipotency is under active investigation. Here Gattinoni et al. characterize a subset of human T cells that phenotypically resemble naive T cells yet have properties associated with memory T cells. These T cells show enhanced ability to self renew and to give rise to differentiated memory cell subsets, suggesting a stem cell–like functionality. Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells. These cells, specific to multiple viral and self-tumor antigens, were found within a CD45RO−, CCR7+, CD45RA+, CD62L+, CD27+, CD28+ and IL-7Rα+ T cell compartment characteristic of naive T cells. However, they expressed large amounts of CD95, IL-2Rβ, CXCR3, and LFA-1, and showed numerous functional attributes distinctive of memory cells. Compared with known memory populations, these lymphocytes had increased proliferative capacity and more efficiently reconstituted immunodeficient hosts, and they mediated superior antitumor responses in a humanized mouse model. The identification of a human stem cell–like memory T cell population is of direct relevance to the design of vaccines and T cell therapies.
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