生物
表观遗传学
组蛋白甲基化
组蛋白密码
癌症表观遗传学
表观遗传学
组蛋白甲基转移酶
DNA甲基化
EZH2型
体育锻炼的表观遗传学
组蛋白
神经发生的表观遗传调控
遗传学
组蛋白H2A
组蛋白H3
DNA
基因
核小体
基因表达
标识
DOI:10.1016/j.gde.2005.08.002
摘要
DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the three best-characterized covalent modifications associated with a repressed chromatin state. Recent advances highlight an essential, intricate web of interactions among these processes, generating a self-reinforcing, self-perpetuating cycle of epigenetic events that lead to long-term transcriptional repression. Histone deacetylation and methylation at lysine 9 of H3 might also contribute to the establishment of DNA methylation patterns, a long-standing mystery in epigenetics. What's more, recent clues suggest a potential link between CpG methylation and other histone modifications. A complex picture is emerging in which DNA methylation and histone modifications work hand-in-hand as parts of an epigenetic program that integrates gene-silencing networks within the cell.
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