免疫系统
嵌合抗原受体
医学
细胞因子
细胞因子释放综合征
免疫学
T细胞
癌症免疫疗法
免疫失调
免疫疗法
内科学
癌症研究
心脏病学
临床试验
不利影响
炎症
作者
Alan H. Baik,Olalekan O. Oluwole,Douglas B. Johnson,Nina Shah,Joe‐Elie Salem,Katy K. Tsai,Javid Moslehi
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2021-05-28
卷期号:128 (11): 1780-1801
被引量:38
标识
DOI:10.1161/circresaha.120.315894
摘要
Immune-based therapies have revolutionized cancer treatments. Cardiovascular sequelae from these treatments, however, have emerged as critical complications, representing new challenges in cardio-oncology. Immune therapies include a broad range of novel drugs, from antibodies and other biologics, including immune checkpoint inhibitors and bispecific T-cell engagers, to cell-based therapies, such as chimeric-antigen receptor T-cell therapies. The recognition of immunotherapy-associated cardiovascular side effects has also catapulted new research questions revolving around the interactions between the immune and cardiovascular systems, and the signaling cascades affected by T cell activation, cytokine release, and immune system dysregulation. Here, we review the specific mechanisms of immune activation from immunotherapies and the resulting cardiovascular toxicities associated with immune activation and excess cytokine production.
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