生物
器官发生
神经科学
人脑
疾病
人类疾病
神经干细胞
计算生物学
干细胞
细胞生物学
遗传学
基因
病理
医学
作者
Kevin W. Kelley,Sergiu P. Pașca
出处
期刊:Cell
[Elsevier]
日期:2022-01-01
卷期号:185 (1): 42-61
被引量:103
标识
DOI:10.1016/j.cell.2021.10.003
摘要
The construction of the human nervous system is a distinctly complex although highly regulated process. Human tissue inaccessibility has impeded a molecular understanding of the developmental specializations from which our unique cognitive capacities arise. A confluence of recent technological advances in genomics and stem cell-based tissue modeling is laying the foundation for a new understanding of human neural development and dysfunction in neuropsychiatric disease. Here, we review recent progress on uncovering the cellular and molecular principles of human brain organogenesis in vivo as well as using organoids and assembloids in vitro to model features of human evolution and disease.
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