熊去氧胆酸
失调
普氏粪杆菌
胃肠病学
内科学
肠道菌群
微生物群
胆汁酸
蔷薇花
医学
原发性硬化性胆管炎
生物
拟杆菌
免疫学
细菌
生物信息学
遗传学
疾病
作者
Weijia Han,Chunyang Huang,Qi Zhang,Shuhui Tao,Xiaomin Hu,Jianguo Xu,Ronglong Jiang,Bin Xu,Yanmin Liu,Jinlin Hou
摘要
The prognosis of primary bile cholangitis (PBC) is linked to gut microbiota dysbiosis. This study investigated the association between the gut microbiome and elevated total bilirubin (TB) level in PBC patients treated with ursodeoxycholic acid (UCDA).A total of 47 PBC patients with 12 months of UCDA treatment were enrolled. Patients were divided into the TB (+) (TB>1× upper limit of the normal range [ULN]; n = 20) and TB(-) (TB≤1× ULN; n = 27) groups. Stool and serum specimens were collected, and microbiota composition and functional characteristics in the 2 groups were evaluated by 16S RNA gene sequencing and bioinformatic analysis.Bacterial diversity was lower in the TB(+) group than in the TB(-) group, although there was no significant difference in bacterial community profile. The phylum Saccharibacteria showed differential abundance in the 2 groups. Meanwhile, the TB(-) group had lower abundance of the Gemmiger, Blautia, Anaerostipes and Coprococcus genera than the TB(+) group, whereas Holdemania was absent. The abundance of Gemmiger formicillis and Coprococcus eutactus was positively correlated with that of Faecalibacterium prausnitzii, while Blautia, Anaerostipes and Coprococcus were negatively correlated with total bile acid level.TB level in PBC patients treated for 12 months with UCDA is associated with a distinct gut microbiome profile.
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