化学
表面改性
碘苯
催化作用
惰性
碘
激进的
偶联反应
组合化学
有机化学
高分子化学
光化学
药物化学
作者
Fufang Wu,Han Xuanzhen,Xuejian Li,Xiaobao Shen,Chang Wang,Zhimei Tian,Bin Cheng,Jingbin Zhang,Sheng Liangquan,Hongbin Zhai
标识
DOI:10.1038/s42004-021-00480-8
摘要
Abstract Cross-dehydrogenative coupling reactions provide a method to construct new chemical bonds by direct C–H activation without any pre-functionalization. Compared to functionalization of a C–H bond α- to ether oxygen, α- to carbonyl, or at a benzylic position, functionalization of unactivated hydrocarbons is difficult and often requires high temperatures, a transition-metal catalyst, or a superstoichiometric quantity of volatile, toxic, and explosive tert- butylhydroperoxide. Here, a cross-dehydrogenative C–O coupling reaction of N-hydroxyphthalimide with unactivated alkanes, nitriles, ethers, and thioethers has been realized by using iodobenzene diacetate as the radical initiator. The current protocol enables efficient functionalization of unactivated hydrocarbons and nitriles through inert C(sp 3 )–H bond activation under mild reaction conditions. O-substituted NHPI derivatives are generated in good yields under metal-free conditions.
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